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Chemical Structure : BAY-069
Catalog No.: PC-49389Not For Human Use, Lab Use Only.
BAY-069 (BAY069) is a potent, selective branched-chain amino acid transaminase BCAT1/2 inhibitor with IC50 of 31/153 nM, respectively.
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BAY-069 (BAY069) is a potent, selective branched-chain amino acid transaminase BCAT1/2 inhibitor with IC50 of 31/153 nM, respectively.
BAY-069 is highly selective for BCAT1/2, and shows no activity against aspartate transaminases (GOT1 and GOT2, glutamate-oxaloacetate transaminase, IC50>50 μM), also is inactive against an protease panel (30 proteases) and kinase panel (30 kinases).
BAY-069 increases cellular branched-chain amino acid (BCAA) in tumor cell lines (U-87 MG and MDA-MB-231) with IC50 of 358 and 874 nM, respectively.
BAY-069 does not inhibit cell proliferation of U-87 MG (high BCAT1 expression) and MDA-MB-231 (high BCAT2 expression) cells.
BAY-069 is a valuable tool to better understand the biology and pharmacology of BCAT inhibition in the field of tumor metabolism.
| M.Wt | 446.810 | |
| Formula | C22H14ClF3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Judith Günther, et al. J Med Chem. 2022 Oct 19. doi: 10.1021/acs.jmedchem.2c00441.
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