You are here:Home-Chemical Inhibitors & Agonists-PI3K/Akt/mTOR Pathway-AMPK-BAY-3827
BAY-3827

Chemical Structure : BAY-3827

CAS No.: 2377576-35-5

BAY-3827 (BAY3827)

Catalog No.: PC-35331Not For Human Use, Lab Use Only.

BAY-3827 (BAY3827) is a potent, selective inhibitor of AMPK with IC50 of 0.4 nM (10 µM ATP) and 15 nM (2 mM ATP), respectively.

Packing Price Stock Quantity
5 mg $138 In stock
10 mg $218 In stock
25 mg $368 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAY-3827 (BAY3827) is a potent, selective inhibitor of AMPK with IC50 of 0.4 nM (10 µM ATP) and 15 nM (2 mM ATP), respectively.
BAY-3827 is a tool compound to evaluate the therapeutic potential of AMPK inhibition in MYC-dependent tumors.
BAY-3827 strongly inhibits Acetyl-CoA carboxylase (ACC) phosphorylation in COLO 320DM and IMR-32 cells, but fails to inhibit the proliferation of cells with dysregulated c-MYC or N-MYC.

Physicochemical Properties

M.Wt 468.536
Formula C27H25FN6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(5-(3,5-dicyano-1,2,6-trimethyl-1,4-dihydropyridin-4-yl)-6-fluoro-7-methyl-1H-indazol-3-yl)-2-ethylbenzamide

References

1. Clara Lemos, et al. Abstract 5873: BAY-3827, a selective inhibitor of AMPK for the evaluation of the role of AMPK in Myc-dependent tumors. AACR.2018.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: