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Chemical Structure : BAY-598
CAS No.: 906919-67-2
Catalog No.: PC-60420Not For Human Use, Lab Use Only.
BAY-598 (BAY598) is a potent, selective, and cell-active, substrate-competitive inhibitor of SMYD2 with IC50 of 27±7 nM in the biochemical SPA assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
| 100 mg | Get quote |
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BAY-598 (BAY598) is a potent, selective, and cell-active, substrate-competitive inhibitor of SMYD2 with IC50 of 27±7 nM in the biochemical SPA assay.
BAY-598 displays >100-fold selectivity over other HMTases (SMYD3, SUV420H1, SUV420H2, etc.) and other non-epigenetic targets.
BAY-598 inhibits the methylation of p53K370 in cells with IC50 <1 uM, has properties that are compatible with in vivo experiments.
| M.Wt | 525.3 | |
| Formula | C22H20Cl2F2N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S,Z)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol-4-yl)-N-ethyl-2-hydroxyacetamide |
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1. Eggert E, et al. J Med Chem. 2016 May 26;59(10):4578-600.
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