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BAY2416964

Chemical Structure : BAY2416964

CAS No.: 2242464-44-2

BAY2416964 (BAY 2416964, BAY-2416964)

Catalog No.: PC-38065Not For Human Use, Lab Use Only.

BAY2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist with IC50 of 341 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BAY2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist with IC50 of 341 nM.
BAY 2416964 potently and selectively inhibited AhR activation induced by either exogenous or endogenous AhR ligands.
BAY 2416964 restored immune cell function in human and mouse cells, and furthermore enhanced antigen-specific cytotoxic T cell responses and killing of tumor spheroids.
BAY 2416964 induced a proinflammatory tumor microenvironment, and demonstrated antitumor efficacy in a syngeneic cancer model in mice.

Physicochemical Properties

M.Wt 387.824
Formula C18H18ClN5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S)-6-(4-chlorophenyl)-N-(1-hydroxypropan-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide

References

1. patent WO2018146010A1, example 192.
2, Li Wen, et al. Cell Death Dis. 2023 Jan 12;14(1):18.

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