You are here:Home-Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-Aryl hydrocarbon Receptor (AhR)

Request The Product List ofAryl hydrocarbon Receptor (AhR) Aryl hydrocarbon Receptor (AhR)

Cat. No. Product Name CAS No. Information
PC-61627

FICZ

172922-91-7

FICZ is a high affinity aryl hydrocarbon receptor (AhR) agonist with Kd of 70 pM; induces transient expression of CYP1A1 in vitro, and potentiates NK cell IFN-γ production and cytolytic activity; enhances NK cell control of tumors in an NK cell- and AhR-dependent manner in vivo; an endogenous AhR ligand.

PC-45600

ITE

448906-42-1

A endogenous ligand, potent aryl hydrocarbon receptor (AhR) agonist in vitro; activates the murine AhR in vivo, but does not induce toxicity; induces the differentiation of stem-like cancer cells and reduces their tumorigenic potential in both subcutaneous and orthotopic xenograft tumour models.

PC-43148

CH-223191

301326-22-7 CH-223191 is a potent, specific antagonist of AhR (aryl hydrocarbon receptor), potently inhibits TCDD-induced AhR-dependent transcription with IC50 of 0.03 uM; shows more inhibitory potency and no agonist-like effect, compared with flavone, resveratrol, and α-naphthoflavone, as well as estrogenic potency; inhibits TCDD-AhR binding and TCDD-induced nuclear translocation and DNA binding of AhR, prevents the expression of cytochrome P450 enzymes, target genes of the AhR; potently prevents TCDD-elicited cytochrome P450 induction, liver toxicity, and wasting syndrome in mice
PC-61319

TCDD

1746-01-6 A potent AHR (aryl hydrocarbon receptor) agonist that induces degradation of AhR by the ubiquitin-proteasome pathway; suppresses the transcription of PEPCK and decreases Sirtuin 1 activation of PGC1α; also blocks cNK development and supports group 3 innate lymphoid cell (ILC3) differentiation.
PC-60778

CH223191

301326-22-7 A potent, specific aryl hydrocarbon receptor (AhR) antagonist that potently inhibits TCDD-induced AhR-dependent transcription with IC50 of 0.03 uM; shows no agonist-like effect, and no activity on estrogen receptor; inhibits TCDD-AhR binding and TCDD-induced nuclear translocation and DNA binding of AhR, blocks TCDD-mediated cytochrome P450 expression (CYP1A1) in HepG2 cells; prevents TCDD-elicited cytochrome P450 induction, liver toxicity, and wasting syndrome in mice.
PC-60777

Phortress

328087-38-3 The L-lysylamide prodrug of 5F-203 (NSC703786), a potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway; causes MCF-7 sensitive cells to arrest in G(1) and S phase, and induces DNA adduct formation, in contrast to AhR-deficient AH(R100) variant MCF-7 cells, induces CYP1A1 and CYP1B1 transcription; demonstrats antitumor activity in vivo.
PC-60776

5F 203

260443-89-8 A potent, selective antitumour agent through activation the aryl hydrocarbon receptor (AhR) pathway; causes MCF-7 sensitive cells to arrest in G(1) and S phase, and induces DNA adduct formation, in contrast to AhR-deficient AH(R100) variant MCF-7 cells, induces CYP1A1 and CYP1B1 transcription; L-lysylamide prodrug Phortress (NSC 710305) demonstrats antitumor activity in vivo.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:
Contact Us sales@probechem.com