BAY 3389934 | FIIa/Xa inhibitor | Probechem Biochemicals

Chemical Structure : BAY 3389934

BAY 3389934 (BAY3389934)

Catalog No.: PC-24671Not For Human Use, Lab Use Only.

BAY 3389934 is a potent and highly selective, direct dual FIIa/Xa inhibitor with IC50 of 4.9/0.66 nM (in buffer) and 22/9.2 nM (in plasma) respectively.

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Biological Activity

BAY 3389934 is a potent and highly selective, direct dual FIIa/Xa inhibitor with IC50 of 4.9/0.66 nM (in buffer) and 22/9.2 nM (in plasma) respectively.

BAY3389934 has IC50 values of 31 and 5.3 nM (FIIa/FXa) for rabbit and 26 and 16 nM (FIIa/FXa) for minipig plasma.

BAY3389934 has EC200 values of 0.32 μM (PT) and 0.22 μM (aPTT) for in vitro anticoagulant activity.

BAY3389934 (0.23 μM) doubled the CT value in the ROTEM (EXTEM) whole blood assay.

BAY3389934 inhibits pre-existing thrombin by potent inhibition of TF-triggered ongoing, normalizes LPS-induced CT in human whole blood at 130 nM.

BAY3389934 strongly reduced the hypercoagulatory state and protected from organ damage in a baboon model of Staphylococcus aureus sepsis.

BAY3389934 showed high selectivity within the serine protease target family (Table 7), no significant off-target effects on a broad range of targets, including GPCRs, ion channels, nuclear hormone receptors, and other proteins and enzymes (>70 targets).

Physicochemical Properties

M.Wt	624.12
Formula	C26H30ClN5O7S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-methyl-1H-imidazol-2-yl)ethyl (S)-3-(5-chlorothiophene-2-carboxamido)-2-((2-ethyl-3-((S)-3-hydroxy-2-oxopyrrolidin-1-yl)phenyl)sulfonamido)propanoate

References

1. Robert Silasi, et al. Blood (2024) 144 (Supplement 1): 3988.

2. Patent WO2023031083 A1.

BAY 3389934 (BAY3389934)

Biological Activity

Physicochemical Properties

References

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