BCL6/GSPT1 degrader A5

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Chemical Structure : BCL6/GSPT1 degrader A5

Catalog No.: PC-28733Not For Human Use, Lab Use Only.

BCL6/GSPT1 degrader A5 is an effective, dual BCL6/GSPT1 degrader with DC50 of 0.48 nM (BCL6) in Farage cells, demonstrates excellent antiproliferative effects across multiple lymphoma cell lines (Farage cells, IC50=0.413 uM), induces DNA damage, cell cycle arrest and apoptosis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BCL6/GSPT1 degrader A5 is an effective, dual BCL6/GSPT1 degrader with DC50 of 0.48 nM (BCL6) in Farage cells, demonstrates excellent antiproliferative effects across multiple lymphoma cell lines (Farage cells, IC50=0.413 uM), induces DNA damage, cell cycle arrest and apoptosis.

Physicochemical Properties

M.Wt	1005.47
Formula	C47H57ClN10O13
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Piperidinecarboxamide, 1-[5-chloro-4-[[1,2-dihydro-8-methoxy-1-methyl-3-[2-(methylamino)-2-oxoethoxy]-2-oxo-6-quinolinyl]amino]-2-pyrimidinyl]-N-[14-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12-tetraoxatetradec-1-yl]-

References

1. Rong Hu, et al. Eur J Med Chem. 2026 Mar 5:305:118567.

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