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Chemical Structure : BDK inhibitor BT2
CAS No.: 34576-94-8
Catalog No.: PC-49378Not For Human Use, Lab Use Only.
BDK inhibitor BT2 is a small molecule allosteric inhibitor of BCKDC kinase (BDK) with IC50 of 3.19 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $148 | In stock | |
| 100 mg | $228 | In stock | |
| 1 g | Get quote |
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BDK inhibitor BT2 is a small molecule allosteric inhibitor of BCKDC kinase (BDK) with IC50 of 3.19 uM.
BDK inhibitor BT2 significantly increases BCKDC activity in wild-type and MSUD cells the mitochondrial branched-chain α-ketoacid dehydrogenase complex (BCKDC).
BDK inhibitor BT2 binds to the same site in BDK as other known allosteric BDK inhibitors, including (S)-α-cholorophenylproprionate ((S)-CPP).
Administration of BT2 at 20 mg/kg/day to wild-type mice for 1 week leads to nearly complete dephosphorylation and maximal activation of BCKDC in heart, muscle, kidneys, and liver with reduction in plasma BCAA concentrations.
BT2 treatment reduced steatosis and/or inflammation, improved sulin sensitivity in HFD-fed and lean mice.
| M.Wt | 247.089 | |
| Formula | C9H4Cl2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3,6- dichlorobenzo[b]thiophene-2-carboxylic acid |
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1. Shih-Chia Tso, et al. J Biol Chem. 2014 Jul 25;289(30):20583-93.
2. Bollinger E, et al. Mol Metab. 2022 Oct 8:101611.
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