BDM71230 | IDE activator | Probechem Biochemicals

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Chemical Structure : BDM71230

BDM71230 (BDM-71230)

Catalog No.: PC-26428Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BDM71230 is a potent, small molecule Insulin-Degrading Enzyme (IDE) activator with EC50 of 1.9 uM in glucose stimulated insulin secretion (GSIS) by pancreatic β-cells assay, 4.1-fold activation at 100 uM.
BDM71230 decreases glucose-stimulating insulin secretion in β-cells.
BDM71230 (50 mg/kg, i.p.) decreases insulin secretion significantly for medium and high glucose stimulation in mice for oral glucose tolerance test (OGTT).

Physicochemical Properties

M.Wt	431.52
Formula	C25H26FN5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4-Dihydro-1H-isoquinolin-2-yl-[1-[4-(4-fluoroanilino)pyrimidin-2-yl]-4-piperidyl]methanone

References

1. El Bakali J, et al. Eur J Med Chem. 2026 Mar 15;309:118740.

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BDM71230 (BDM-71230)

Biological Activity

Physicochemical Properties

References

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