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Chemical Structure : BDTX-1535
Catalog No.: PC-21566Not For Human Use, Lab Use Only.
BDTX-1535 is a 4th generation, irreversible, CNS penetrant, potent, wild type sparing EGFR inhibitor, targets a family of oncogenic EGFR extracellular domain alterations and amplification in GBM, and EGFR resistance mutations in NSCLC.
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BDTX-1535 is a 4th generation, irreversible, CNS penetrant, potent, wild type sparing EGFR inhibitor, targets a family of oncogenic EGFR extracellular domain alterations and amplification in GBM, and EGFR resistance mutations in NSCLC.
BDTX-1535 achieves potent anti-tumor activity against EGFR alterations and amplification across models including NSCLC and GBM PDX and intracranial tumors.
| M.Wt | 561.06 | |
| Formula | C30H30ClFN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Matthew O'Connor, et al. Cancer Res (2023) 83 (7_Supplement): 3396.
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