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Chemical Structure : BDTX-189
CAS No.: 2414572-47-5
Catalog No.: PC-73140Not For Human Use, Lab Use Only.
BDTX-189 (Tuxobertinib) is a potent, selective, irreversible inhibitor of allosteric EGFR and HER2 mutant variants.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $28 | In stock | |
| 10 mg | $88 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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BDTX-189 (Tuxobertinib) is a potent, selective, irreversible inhibitor of allosteric EGFR and HER2 mutant variants.
BDTX-189 (Tuxobertinib) shows KD value s of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively.
BDTX-189 (Tuxobertinib) inactivates multiple allosteric ERBB mutants in vivo, achieves dose-dependent regression of allosteric HER2 and EGFR tumors.
| M.Wt | 561.03 | |
| Formula | C29H29ClN6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-(2-morpholinoethoxy)quinazolin-6-yl)acrylamide |
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1. Elizabeth Buck, et al. BDTX-189, a Potent and Selective Inhibitor of Allosteric EGFR and HER2 Oncogenic Mutations.
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