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BF 844

Chemical Structure : BF 844

CAS No.: 1404506-35-9

BF 844 (BioFocus 844)

Catalog No.: PC-62222Not For Human Use, Lab Use Only.

BF 844 (BioFocus 844) is a small molecules capable of stabilizing mutant USH3 mutation CLRN1(N48K).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BF 844 (BioFocus 844) is a small molecules capable of stabilizing mutant USH3 mutation CLRN1(N48K); effectively attenuated progressive hearing loss and prevented deafness in mouse model potentially prevents both sensory deficiencies in patients with USH3.

Physicochemical Properties

M.Wt 378.85
Formula C21H19ClN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazin-1-yl)-2-methylpropan-2-ol

References

1. Alagramam KN, et al. Nat Chem Biol. 2016 Jun;12(6):444-51.

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