Chemical Structure : BH3I-1
CAS No.: 300817-68-9
Catalog No.: PC-42125Not For Human Use, Lab Use Only.
A small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay.
Packing | Price | Stock | Quantity |
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5 mg | $80 | In stock | |
10 mg | $120 | In stock | |
25 mg | $240 | In stock | |
50 mg | $400 | In stock |
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A small-molecule Bcl-2 antagonist that inhibits the ineraction of Bak BH3 and Bcl-xL with Ki of 2.4 uM in FP binding assay; specifically blocks the BH3-domain-mediated heterodimerization between Bcl-2 family members in vitro and in vivo and induces apoptosis; also potently inhibits p53/hDM2 with Kd of 5.3 uM.
M.Wt | 400.3105 | |
Formula | C15H14BrNO3S2 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 3.9 mg/mL |
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Chemical Name/SMILES |
3-Thiazolidineacetic acid, 5-[(4-bromophenyl)methylene]-α-(1-methylethyl)-4-oxo-2-thioxo- |
1. Degterev A, et al. Nat Cell Biol. 2001 Feb;3(2):173-82.
2. Wang L, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):236-40.
3. Porter JR, et al. Chem Commun (Camb). 2010 Nov 14;46(42):8020-2.
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