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Chemical Structure : BI-1622
Catalog No.: PC-49227Not For Human Use, Lab Use Only.
BI-1622 (BI 1622) is a potent, selective, covalent and orally active HER2 inhibitor with IC50 of 7 nM, potently inhibits HER2 exon 20 mutants while sparing WT EGFR.
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BI-1622 (BI 1622) is a potent, selective, covalent and orally active HER2 inhibitor with IC50 of 7 nM, potently inhibits HER2 exon 20 mutants while sparing WT EGFR.
BI-1622 (5 uM) inhibits the proliferation of HER2-dependent cell lines, dose-dependently decreases pHER2 and pERK levels in NCI-H2170 HER2YVMA and PC-9 HER2YVMA cells.
BI-1622 inhibits tumor growth and inhibits oncogenic signaling in preclinical xenograft models of HER2 exon 20 mutant non-small cell lung cancer.
| M.Wt | 508.54 | |
| Formula | C26H24N10O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. To C, et al. Nat Cancer. 2022 Apr;3(4):402-417.
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