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Chemical Structure : BI-3231
Catalog No.: PC-49633Not For Human Use, Lab Use Only.
BI-3231 (BI 3231) is a potent, selective HSD17B13 (hydroxysteroid 17β-dehydrogenase 13) inhibitor with enzyme IC50 of 1 and 14 nM for human and mouse HSD17B13, respectively.
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BI-3231 (BI 3231) is a potent, selective HSD17B13 (hydroxysteroid 17β-dehydrogenase 13) inhibitor with enzyme IC50 of 1 and 14 nM for human and mouse HSD17B13, respectively.
BI-3231 displays excellent selectivity versus the structurally related homolog HSD17B11 (IC50>10 uM), as well as good selectivity in a commercial SafetyScreen44 panel, Cerep.
BI-3231 is the first potent and selective chemical probe reported for HSD17B13, a potential new target for the treatment of NASH and other liver diseases.
| M.Wt | 380.37 | |
| Formula | C16H14F2N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thamm S, et al. J Med Chem. 2023 Feb 2. doi: 10.1021/acs.jmedchem.2c01884.
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