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BI-3802

Chemical Structure BI-3802

CAS No.: 2166387-65-9

BI-3802 (BI3802;BI 3802)

Catalog No.: PC-60949Not For Human Use, Lab Use Only.

BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM; inhibits the BCL6/Co-repressor complex formation with IC50 of 43 nM in vitro, also is a potent and efficacious degrader of the BCL6 protein in many DLBCL cell lines (DC50=20 nM in SU-DHL-4 cells); BI-3802 is a valuable probe compound for testing hypotheses around BCL6 biology.

Physicochemical Properties

M.Wt 484.985
Formula C24H29ClN6O3
CAS No. 2166387-65-9
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
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Solubility

Chemical Name

2-((6-((5-chloro-2-((3S,5R)-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)-N-methylacetamide

Clinical Information

References

1. Kerres N, et al. Cell Rep. 2017 Sep 19;20(12):2860-2875.

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