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Chemical Structure : BI-4020
CAS No.: 2664214-60-0
Catalog No.: PC-73104Not For Human Use, Lab Use Only.
BI-4020 (BI 4020) is a potent, next generation, wt-sparing inhibitor of EGFR mutant T790M and/or C797S, and EGFRdel19 T790M C797S (0.2 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $248 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $588 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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BI-4020 (BI 4020) is a potent, next generation, wt-sparing inhibitor of EGFR mutant T790M and/or C797S, and EGFRdel19 T790M C797S (0.2 nM).
BI-4020 inhibits not only the triple mutant EGFRdel19 T790M C797S variant but also the double mutant EGFRdel19 T790M and primary mutant EGFRdel19 while sparing activity against EGFRwt.
BI-4020 shows high potency on EGFR mutant cells, high kinome selectivity, and good DMPK properties.
BI-4020 exhibites tumor regressions in the human PC-9 (EGFRdel19 T790M C797S) triple mutant NSCLC xenograft model in mice.
| M.Wt | 542.688 | |
| Formula | C30H38N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in DMSO (54.3 mg/mL) |
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| Chemical Name/SMILES |
(R,E)-11,26,7-Trimethyl-56-((4-methylpiperazin-1-yl)methyl)-52,53-dihydro-11H,51H-11-oxa-4-aza-5(2,1)-benzo[d]imidazola-2(2,4)-pyridina-1(4,5)-pyrazolacycloundecaphan-3-one |
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1. Engelhardt H, et al. J Med Chem. 2019 Nov 27;62(22):10272-10293.
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