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Chemical Structure : BI-6c9
CAS No.: 791835-21-7
Catalog No.: PC-49740Not For Human Use, Lab Use Only.
BI-6C9 is a specific small molecule inhibitor of BH3 interacting-domain death agonist (Bid) with Kd of 20 uM, blocks the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | $728 | In stock | |
| 1 g | Get quote |
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BI-6C9 is a specific small molecule inhibitor of BH3 interacting-domain death agonist (Bid) with Kd of 20 uM, blocks the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria.
BI-6C9 (10 µM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.
BI-6C9 prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation.
BH3 interacting domain death agonist (Bid), a substrate of caspase-8, is activated in the Fas/Apo-1 (CD95), tumor necrosis factor (TNF)-α, and tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptor-mediated cell death.
| M.Wt | 471.59 | |
| Formula | C23H25N3O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[4-[(4-Aminophenyl)thio]phenyl]-4-[[(4-methoxyphenyl)sulfonyl]amino]-Butanamide |
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1. Zhou H, et al. Mol Cancer. 2014 Mar 16;13:59.
2. Landshamer, S., et al. Cell Death Differ. 15(10), 1553-1563 (2008).
3. Culmsee, C. et al. J. Neurosci. 25(44), 10262-10272 (2005).
4. Becattini, B.,et al. Proc. Natl. Acad. Sci. USA 103(3), 12602-12606 (2006).
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