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Chemical Structure : BI-8128
Catalog No.: PC-21465Not For Human Use, Lab Use Only.
BI-8128 is a potent, selective, reversible and orally bioavailable fourth generation EGFR inhibitor, potently inhibits oncogenic EGFR variants del19 and L858R as well as the acquired EGFR resistance mutations T790M and C797S.
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BI-8128 is a potent, selective, reversible and orally bioavailable fourth generation EGFR inhibitor, potently inhibits oncogenic EGFR variants del19 and L858R as well as the acquired EGFR resistance mutations T790M and C797S.
BI-8128 demonstrates potent, low nanomolar anti-proliferative activity in Ba/F3 cells that are dependent on the activity of human EGFR variants del19, del19 T790M C797S, L858R, and L858R T790M C797S.
BI-8128 potently inhibits the two major primary oncogenic EGFR variants del19 and L858R, in the presence and absence of the acquired EGFR resistance mutations T790M and C797S, while sparing wild-type EGFR.
| M.Wt | 610.72 | |
| Formula | C32H38N10O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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