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Chemical Structure : BI-853520
CAS No.: 1227948-82-4
Catalog No.: PC-60275Not For Human Use, Lab Use Only.
Ifebemtinib (BI 853520) is potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $458 | In stock | |
| 10 mg | $728 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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Ifebemtinib (BI 853520) is potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays.
BI 853520 inhibits only 4 enzymes at 10 uM in a panel of 264 tyrosine and serine/threonine kinases.
BI 853520 inhibits the colony formation of PC-3 cells with EC50 of 3 nM.
BI 853520 suppresses PTK2 autophosphorylation in tissue samples from both human tumor xenografts and mouse skin.
BI 853520 demonstrates anti-tumor activity in vivo.
| M.Wt | 588.56 | |
| Formula | C28H28F4N6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-fluoro-5-methoxy-4-((4-((2-methyl-3-oxoisoindolin-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide |
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1. Roy-Luzarraga M, et al. Clin Cancer Res. 2016 Aug 1;22(15):3718-24.
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