BI-8925 | MLKL inhibitor | Probechem Biochemicals

Chemical Structure : BI-8925

BI-8925 (BI 8925)

Catalog No.: PC-24410Not For Human Use, Lab Use Only.

BI-8925 is a potent, selective and covalent inhibitor of mixed lineage kinase domain-like (MLKL), inhibits necroptosis in Jurkat and U937 cells with an IC50 of 541 and 271 nM, respectively.

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Biological Activity

BI-8925 is a potent, selective and covalent inhibitor of mixed lineage kinase domain-like (MLKL), inhibits necroptosis in Jurkat and U937 cells with an IC50 of 541 and 271 nM, respectively.

Physicochemical Properties

M.Wt	346.36
Formula	C12H18N4O6S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((2-methoxyethoxy)methyl)-1,3-dimethyl-8-(methylsulfonyl)-3,7-dihydro-1H-purine-2,6-dione

References

1. Martin Rübbelke, et al. J Med Chem. 2021 Nov 11;64(21):15629-15638.

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BI-8925 (BI 8925)

Biological Activity

Physicochemical Properties

References

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