| Cat. No. |
Product Name |
Information |
| PC-20851 |
KC-130
ZAK inhibitor
|
KC-130 (KC130, ZAK inhibitor 8) is a potent, selective and covalent leucine-zipper and sterile-α motif kinase (ZAK) inhibitor with IC50 of 11.5 nM. |
| PC-43118 |
URMC-099
MLK3 inhibitor
|
URMC-099 is a potent, orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3 (MLK3) with IC50 of 14 nM. |
| PC-70325 |
GW 806742X
|
GW 806742X (T0446) is a small molecule MLKL (Mixed Lineage Kinase Domain-Like) interactor that binds the MLKL pseudokinase domain (Kd=9.3 uM), retards membrane association to inhibit necroptosis. |
| PC-70175 |
M-443
MRK (ZAK) inhibitor
|
M-443 (M443) is a specific, irreversible inhibitor of MLK-related kinase MRK (ZAK), does not inhibit Bcr-Abl. |
| PC-70174 |
CEP-1347
|
CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM. |
| PC-42202 |
Necrosulfonamide
MLKL inhibitor
|
Necrosulfonamide is a small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation. |
| PC-21159 |
MLKL inhibitor P28
MLKL inhibitor
|
MLKL inhibitor P28 is a potent inhibitor of necroptosis via MLKL inhibition (EC50=10.3 uM), blocks oligomerization and translocation of MLKL. |
| PC-21158 |
TC13172
MLKL inhibitor
|
TC13172 (TC 13172) is a highly potent necroptosis inhibitor targeting the mixed lineage kinase domain-like protein (MLKL), inhibits necroptosis with IC50 of 2 nM in TSZ-induced necroptosis assays in HT-29 cells. |
