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Chemical Structure : BI-9627
Catalog No.: PC-35034Not For Human Use, Lab Use Only.
BI-9627 is a potent, selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) with pHi change IC50 of 6 nM, displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform.
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BI-9627 is a potent, selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1) with pHi change IC50 of 6 nM, displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform; also shows high potency in the platelet swelling assay with IC50 of 31 nM; demonstrates IC50 >30 μM across all CYP isoforms tested; exhibits profound efficacy, prevents or attenuates ischemia-reperfusion injury in the Langendorff isolated perfused rat heart model.
| M.Wt | 356.349 | |
| Formula | C16H19F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Huber JD, et al. J Med Chem. 2012 Aug 23;55(16):7114-40.
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