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Chemical Structure : BIA 10-2474
CAS No.: 1233855-46-3
Catalog No.: PC-45699Not For Human Use, Lab Use Only.
BIA 10-2474 is a potent FAAH inhibitor with IC50 of 4.9 nM in HEK293T cells expressing the human recombinant enzyme.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $228 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | $548 | In stock | |
| 250 mg | $1080 | In stock | |
| 1 g | Get quote |
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BIA 10-2474 is a potent FAAH inhibitor with IC50 of 4.9 nM in HEK293T cells expressing the human recombinant enzyme.
BIA 10-2474 also inhibits FAAH2, α/β-hydrolase domain-containing protein 6 (ABHD6), carboxylesterase 2 (CES2), and patatin-like phospholipase domain 6 (PNPLA6) with IC50 values of 0.4, 0.081, 2, and 11 μM, respectively.
BIA 10-2474 produces substantial alterations in lipid networks in human cortical neurons
| M.Wt | 300.3556 | |
| Formula | C16H20N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6.4 mg/mL (Need ultrasonic and warming) |
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| Chemical Name/SMILES |
1H-Imidazole-1-carboxamide, N-cyclohexyl-N-methyl-4-(1-oxido-3-pyridinyl)- |
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1. Tong J, et al. J Cereb Blood Flow Metab. 2016 Jan 1:271678X16668890.
2. Kerbrat A, et al. N Engl J Med. 2016 Nov 3;375(18):1717-1725.
3. van Esbroeck ACM, et al. Science. 2017 Jun 9;356(6342):1084-1087.
4. Kiss L, et al. ChemMedChem. 2018 Aug 16. doi: 10.1002/cmdc.201800393.
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