Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BIBU1361
Catalog No.: PC-62998Not For Human Use, Lab Use Only.
BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM)。
BIBU1361 inhibits EGF-induced phosphorylation of EGFR in a dose-dependent manner in A431 cells (EC50=122 nM)。
BIBU1361 demonstrates effectivity in tumour xenografts mice.
| M.Wt | 443.955 | |
| Formula | C22H27ClFN7 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Solca FF, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9.
2. Ghildiyal R, et al. Mol Carcinog. 2013 Dec;52(12):970-82.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
