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Chemical Structure : BIBU1361 dihydrochloride
Catalog No.: PC-62999Not For Human Use, Lab Use Only.
BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).
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BIBU1361 is a potent, selective, orally active EGFR inhibitor with IC50 of 3 nM, shows weak activity against HER2 (IC50=280 nM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM); inhibits EGF-induced phosphorylation of EGFR in a dose-dependent manner in A431 cells (EC50=122 nM); demonstrates effectivity in tumour xenografts mice.
| M.Wt | 516.871 | |
| Formula | C22H29Cl3FN7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Solca FF, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9.
2. Ghildiyal R, et al. Mol Carcinog. 2013 Dec;52(12):970-82.
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