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Chemical Structure : BIBX 1382
CAS No.: 196612-93-8
Catalog No.: PC-42522Not For Human Use, Lab Use Only.
BIBX 1382 (Falnidamol) is a selective EGFR inhibitor with IC50 of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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BIBX 1382 (Falnidamol) is a selective EGFR inhibitor with IC50 of 3 nM.
BIBX 1382 shows weak activity against HER2 (IC50=3.4 uM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).
BIBX 1382 inhibits EGF-induced phosphorylation of EGFR in a dose-dependent manner in A431 cells; orally active in xenografts mice.
| M.Wt | 387.8418 | |
| Formula | C18H19ClFN7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 41 mg/mL |
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| Chemical Name/SMILES |
Pyrimido[5,4-d]pyrimidine-2,8-diamine, N8-(3-chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)- |
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1. Solca FF, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9.
2. Hutzler JM, et al. Drug Metab Dispos. 2014 Oct;42(10):1751-60.
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