Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BIIE0246
Catalog No.: PC-38252Not For Human Use, Lab Use Only.
BIIE0246 (BIIE 0246) is a potent, highly selective non-peptide neuropeptide Y Y2 receptor antagonist with IC50 of 15 nM, >650-fold selectivity over Y1, Y4 and Y5 receptors.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BIIE0246 (BIIE 0246) is a potent, highly selective non-peptide neuropeptide Y Y2 receptor antagonist with IC50 of 15 nM, >650-fold selectivity over Y1, Y4 and Y5 receptors.
1 uM BIIE0246 completely blocked the contraction induced by PYY(3-36), but not that of [Leu(31), Pro(34)]NPY (a Y(1), Y(4) and Y(5) agonist) and hPP (a Y(4) and Y(5) agonist).
BIIE0246 displaced [125I]neuropeptide Y with high affinity (IC(50)=3.3 nM) from the human neuropeptide Y Y(2) receptor and proved to be highly selective.
| M.Wt | 896.066 | |
| Formula | C49H57N11O6 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Doods H,et al. Eur J Pharmacol. 1999 Nov 19;384(2-3):R3-5.
2. Malmström RE. Br J Pharmacol. 2001 Aug;133(7):1073-80.
3. Goumain M, et al. Mol Pharmacol. 2001 Jul;60(1):124-34.
4. Smith-White MA, et al. Br J Pharmacol. 2001 Feb;132(4):861-8.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
