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Chemical Structure : BIO922
CAS No.: 2733445-49-1
Catalog No.: PC-35656Not For Human Use, Lab Use Only.
BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $488 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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BIO922 (BIO 922, BIO-922) is a small molecule PICK1 inhibitor that specificly blocks the PDZ domain-mediated interaction between GluA2 and PICK1 (IC50=69 nM), blocks the effects of Aβ on synaptic transmission and surface receptors.
BIO922 shows >100-fold selectivity over other related PDZ domain-containing proteins, namely PSD-95 and GRIP.
BIO922 stabilizes surface GluA2 and attenuates Aβ-mediated increase in intracellular calcium concentration in cultured hippocampal neurons.
| M.Wt | 545.987 | |
| Formula | C28H27ClF3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-2-(1-(6-chloroquinolin-8-yl)-4-(4-(trifluoromethyl)phenyl)piperidine-4-carboxamido)-3-cyclopropylpropanoic acid |
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1. Lin EYS, et al. Sci Rep. 2018 Sep 7;8(1):13438.
2. Alfonso S, et al. Eur J Neurosci. 2014 Apr;39(7):1225-33.
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