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Chemical Structure : BIX02188
CAS No.: 334949-59-6
Catalog No.: PC-42869Not For Human Use, Lab Use Only.
BIX02188 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 4.3 nM, wekaly inhibits ERK5 catalytic activity (IC50=810 nM) and does not inhibits closely related kinases MEK1, MEK2, ERK2, and JNK2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $195 | In stock | |
| 50 mg | $585 | In stock | |
| 100 mg | $985 | In stock | |
| 500 mg | Get quote |
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BIX02188 is a potent, selective inhibitor of MEK5 catalytic activity with IC50 of 4.3 nM, wekaly inhibits ERK5 catalytic activity (IC50=810 nM) and does not inhibits closely related kinases MEK1, MEK2, ERK2, and JNK2; blocks phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells, also inhibits transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system; induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD.
| M.Wt | 412.4837 | |
| Formula | C25H24N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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| Chemical Name/SMILES |
1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-, (3Z)- |
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1. Li L, et al. Biochem Biophys Res Commun. 2008 May 23;370(1):159-63.
2. Tatake RJ,et al. Biochem Biophys Res Commun. 2008 Dec 5;377(1):120-5.
3. Obara Y, et al. J Biol Chem. 2009 Aug 28;284(35):23564-73.
4. Razumovskaya E, et al. Biochem Biophys Res Commun. 2011 Aug 26;412(2):307-12.
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