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Chemical Structure : BJP-06-005-3
Catalog No.: PC-72215Not For Human Use, Lab Use Only.
BJP-06-005-3 is a potent, selective, covalent, cell-permeable peptide Pin1 inhibitor (Ki=15 nM) that covalently target Cys113, a highly conserved cysteine located in the Pin1 active site.
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BJP-06-005-3 is a potent, selective, covalent, cell-permeable peptide Pin1 inhibitor (Ki=15 nM) that covalently target Cys113, a highly conserved cysteine located in the Pin1 active site.
BJP-06–005-3 potently inhibited Pin1 catalytic activity with an apparent Ki of 48 nM in PPIase assays.
BJP-06-005-3 reduced cell viability cross a panel of cancer cell lines in a dose- and time-dependent manner.
BJP-06-005-3 increased phospho-CDK1 Tyr15 in Pin1-WT PDAC cell, but not in Pin1 KO cells, affected expression of downstream Pin1 substrates, increased c-Myc protein levels, cooperated with KRASG12V degradation.
| M.Wt | 738.283 | |
| Formula | C37H48ClN7O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Benika J Pinch, et al. Nat Chem Biol. 2020 Sep;16(9):979-987.
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