Catalog No.: PC-60338Not For Human Use, Lab Use Only.
BL-1249 (BL1249) is a potent K2P2.1 (TREK-1) channel activator, enhance the activity of TREK1 currents and produces relaxation of 30 mM KCl-induced contractions in rat bladder strips with EC50 of 1.12 uM.
BL-1249 (BL1249) is a potent K2P2.1 (TREK-1) channel activator, enhance the activity of TREK1 currents and produces relaxation of 30 mM KCl-induced contractions in rat bladder strips with EC50 of 1.12 uM.
BL-1249 decreases the number of isovolumic contractions, without significantly affecting blood pressure, in anesthetized rat models.
BL-1249 exhibits bladder versus vascular selectivity both in vitro and in vivo.
