Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BMH-21
CAS No.: 896705-16-1
Catalog No.: PC-43056Not For Human Use, Lab Use Only.
BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BMH-21 is a RNA polymerase I inhibitor with wide and potent antitumorigenic activity across NCI60 cancer cell lines with mean GI50 of 160 nM, interacts with GC-Rich rDNA, potently and rapidly represses RNA polymerase I (Pol I) transcription.
BMH-21 inhibits the expression of 47S rRNA transcript with IC50 of 60 nM, blocks transcription of the rRNA precursor without affecting rRNA maturation, and causes segregation of nucleolar proteins.
BMH-21 causes proteasome-mediated degradation of RPA194 (Pol I catalytic subunit).
BMH-21 activates p53 and inhibits TP53 null and mutant cell lines with GI50 of 110 and 205 nM, respectively.
| M.Wt | 360.4091 | |
| Formula | C21H20N4O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo- |
|
1. Peltonen K, et al. Cancer Cell. 2014 Jan 13;25(1):77-90.
2. Colis L, et al. J Med Chem. 2014 Jun 12;57(11):4950-61.
3. Colis L, et al. Oncotarget. 2014 Jun 30;5(12):4361-9.
4. Peltonen K, et al. Mol Cancer Ther. 2014 Nov;13(11):2537-46.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
