| Cat. No. |
Product Name |
Information |
| PC-28474 |
REV7 inhibitor C10
REV7 inhibitor
|
REV7 inhibitor C10 (Compound 10) is a small-molecule inhibitor targeting the REV3-binding interface of REV7 (MAD2L2) and disrupting the REV7-REV3 protein-protein interaction (IC50=3.9 uM) within DNA polymerase ζ (Pol ζ). |
| PC-28470 |
REV7-IN-1
REV7 inhibitor
|
REV7-IN-1 (REV7/REV3L-IN-1) is a small-molecule inhibitor of the DNA polymerase ζ non-catalytic subunit REV7, inhibits REV7/REV3L interaction with IC50 of 78 uM in FP assays, inhibits DNA interstrand crosslink repair (ICLR), chemosensitizes HeLa cells to cisplatin. |
| PC-28440 |
RP-3467
Polθ inhibitor
|
RP-3467 is a potent, selective inhibitor of DNA polymerase theta (Polθ) helicase domain with EC50 of <0.25 nM, shows no discernible inhibitory activity against other DNA repair-related ATPases WRN, BLM, and FANCM. |
| PC-27659 |
DIQ01
KHSRP inhibitor
|
DIQ01 is a specific small-molecule inhibitor of KH-type splicing regulatory protein (KHSRP), targets KH3 domain of KHSRP (MST Kd=387.4 nM) and disrupts RNA binding, exhibits potent antitumor efficacy. |
| PC-27228 |
ART6043
DNA Polθ inhibitor
|
ART6043 is a potent and selective small molecule inhibitor of DNA polymerase theta (DNA Polθ), inhibits Polθ polymerase domain (residues 1820-2590) with IC50 of 1.3 nM. |
| PC-26687 |
Polθ ATPase inhibitor XL-20
DNA Polθ inhibitor
|
XL-20 is a potent, selective orally bioavailable selenium-containing DNA polymerase theta (Polθ) inhibitor with IC50 of 4.3 nM for Polθ ATPase. |
| PC-25714 |
NSH76
RNA Pol I inhibitor, RRN3 inhibitor
|
NSH76 is a potent and selective RNA polymerase I (Pol I) inhibitor, inhibits Pol I-specific transcription initiation factor RRN3, selectively inhibits Pol I transcription by disrupting the Pol I pre-initiation complex. |
| PC-25710 |
RTx-303
DNA Polθ inhibitor
|
RTx-303 is a potent, selective, allosteric and orally active inhibitor of DNA polymerase θ (Polθ) with IC50 of 5.8 nM, shows no significant inhibition of other eukaryotic DNA polymerases, including the related A-family Polγ. |
| PC-25495 |
RP-2119
DNA Polθ inhibitor
|
RP-2119 (RP2119) is a selective, potent, and bioavailable inhibitor of DNA polymerase theta (Polθ) ATPase inhibitor with IC50 of 0.7 nM (hPOLθ ATPase) in ADP-glo assayss. |
| PC-25300 |
MM927
NVL inhibitor
|
NVL inhibitor MM927 is a bioavailable analog of MM17 and potent inhibitor of 60S ribosomal subunit assembly factor NVL (nuclear valosin-containing protein-like) with IC50 of 51 nM in cells expressing ectopic human NVL, inhibits HCT116 growth in a dose-dependent manner with IC50 of 53 nM. |
| PC-25138 |
YH-0623
POLRMT inhibitor
|
YH-0623 is a potent, selective mitochondrial RNA polymerase (POLRMT) inhibitor with IC50 of 45 nM on the 22Rv1 cell line, significantly reduces the ND1 mitochondrial factor to 14%, demonstrating 1.5-fold greater activity than IMT1B. |
| PC-24850 |
BOB-42
RNA Pol I inhibitor
|
BOB-42 is a small molecule inhibitor of RNA polymerase I (Pol I) with IC50 of 0.04 uM and 0.04 uM for degradation of RPA194 and translocation of NCL resepctively. |
