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Chemical Structure : BML-277
CAS No.: 516480-79-8
Catalog No.: PC-49284Not For Human Use, Lab Use Only.
BML-277 (BML277) is a potent, selective and ATP-competitive inhibitor of Chk2 serine/threonine kinase with IC50 of 15 nM, >1000-fold selectivity over Chk1 and Cdk1/B kinases.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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BML-277 (BML277) is a potent, selective and ATP-competitive inhibitor of Chk2 serine/threonine kinase with IC50 of 15 nM, >1000-fold selectivity over Chk1 and Cdk1/B kinases.
BML-277 dose dependently protects human CD4+ and CD8+ T-cells from apoptosis due to ionizing radiation.
BML-277 specifically inhibit CHK2 phosphorylation at Thr68 at different time course, but not CHK1 phosphorylation.
BML-277 significantly promoted pneumonia symptoms, including mortality, lung infiltration of immune cells, and the abundance of lung pro-inflammatory cytokines in vivo.
BML-277 reduced protein poly(ADP-ribosyl)ation (PARylation), FANCD2 monoubiquitination, homologous recombination and OR CRC cell growth in vitro and in vivo.
| M.Wt | 363.80 | |
| Formula | C20H14ClN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide |
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1. Kristen L Arienti, et al. J Med Chem. 2005 Mar 24;48(6):1873-85.
2. Xie F, et al. Exp Lung Res. 2022 Jan 25:1-8.
3. Hsieh CC, et al. Br J Cancer. 2022 Aug 23. doi: 10.1038/s41416-022-01946-9.
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