BMS-262084 | Tryptase inhibitor, FXIa inhibitor

Chemical Structure : BMS-262084

BMS-262084 (BMS262084)

Catalog No.: PC-25174Not For Human Use, Lab Use Only.

BMS-262084 is a potent and highly selective inhibitor of human tryptase with IC50 of 4 nM, >100-fold selective over Plasmin, Thrombin, uPA and tPA, also is an irreversible inhibitor of factor Xia with IC50 of 2.8 nM, shows antithrombotic effects.

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Biological Activity

BMS-262084 is a potent and highly selective inhibitor of human tryptase with IC50 of 4 nM, >100-fold selective over Plasmin, Thrombin, uPA and tPA, also is an irreversible inhibitor of factor XIa with IC50 of 2.8 nM, shows antithrombotic effects.

Physicochemical Properties

M.Wt	425.49
Formula	C18H31N7O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R)-1-(4-(tert-butylcarbamoyl)piperazine-1-carbonyl)-3-(3-((diaminomethylene)amino)propyl)-4-oxoazetidine-2-carboxylic acid

References

1. Slusarchyk WA, et al. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3235-8.

2. Schumacher WA, et al. Eur J Pharmacol. 2007 Sep 10;570(1-3):167-74.

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BMS-262084 (BMS262084)

Biological Activity

Physicochemical Properties

References

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