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Chemical Structure : BMS-345541
CAS No.: 547757-23-3
Catalog No.: PC-42631Not For Human Use, Lab Use Only.
BMS-345541 is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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BMS-345541 is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM.
BMS-345541 is less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε.
BMS-345541 inhibits LPS-stimulated TNFα, IL-1β, IL-8, and IL-6 in THP-1 cells with IC50 of1-5 uM.
BMS-345541 has excellent pharmacokinetics in mice.
| M.Wt | 291.7792 | |
| Formula | C14H18ClN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,2-Ethanediamine, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-, hydrochloride (1:1) |
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1. Burke JR, et al. J Biol Chem. 2003 Jan 17;278(3):1450-6.
2. McIntyre KW, et al. Arthritis Rheum. 2003 Sep;48(9):2652-9.
3. López-Guerra M, et al. Clin Cancer Res. 2009 Apr 15;15(8):2767-76.
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