Chemical Structure : BMS-345541
CAS No.: 445430-58-0
Catalog No.: PC-42632Not For Human Use, Lab Use Only.
BMS-345541 is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM, less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε.
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| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
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	BMS-345541 is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM, less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε.
	BMS-345541 inhibits LPS-stimulated TNFα, IL-1β, IL-8, and IL-6 in THP-1 cells with IC50 of1-5 uM.
	BMS-345541 has excellent pharmacokinetics in mice.
| M.Wt | 255.3183 | |
| Formula | C14H17N5 | |
| Appearance | Solid | |
| Storage | 
                            
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| Solubility | 
                             10 mM in DMSO  | 
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| Chemical Name/SMILES | 
                             1,2-Ethanediamine, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-  | 
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1. Burke JR, et al. J Biol Chem. 2003 Jan 17;278(3):1450-6.
2. McIntyre KW, et al. Arthritis Rheum. 2003 Sep;48(9):2652-9.
3. López-Guerra M, et al. Clin Cancer Res. 2009 Apr 15;15(8):2767-76.

                
                
                
                
                
                
                
                
            
            
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