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Chemical Structure : BMS-466442
Catalog No.: PC-36150Not For Human Use, Lab Use Only.
BMS-466442 (BMS466442) is small molecule inhibitor of the Alanine-Serine-Cysteine-1 Transporter (ASC-1, SLC7A10), selectively inhibits asc-1 mediated D-serine uptake in human asc-1 expressing cells and primary cultures with IC50 of 36.8 and 19.7 nM, respectively.
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BMS-466442 (BMS466442) is small molecule inhibitor of the Alanine-Serine-Cysteine-1 Transporter (ASC-1, SLC7A10), selectively inhibits asc-1 mediated D-serine uptake in human asc-1 expressing cells and primary cultures with IC50 of 36.8 and 19.7 nM, respectively; BMS-466442 inhibited asc-1 but was not a competitive substrate for this transporter, BMS-466442 is the first reported selective inhibitor of the asc-1 transporter.
| M.Wt | 524.577 | |
| Formula | C30H28N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Brown JM, et al. J Neurochem. 2014 Apr;129(2):275-83.
2. Torrecillas IR, et al. ACS Chem Neurosci. 2019 Mar 14. doi: 10.1021/acschemneuro.9b00019.
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