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Chemical Structure : BMS-599626
CAS No.: 714971-09-2
Catalog No.: PC-42486Not For Human Use, Lab Use Only.
BMS-599626 (AC480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | $598 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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BMS-599626 (AC480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.
BMS-599626 displays 8-fold less potency to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc.
BMS-599626 inhibits the proliferation of tumor cells expressing high levels of HER1 and/or HER2.
BMS-599626 shows potent antitumor activity in a human breast tumor KPL-4 xenograft; orally efficacious.
| M.Wt | 530.5535 | |
| Formula | C27H27FN8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate |
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1. Gavai AV, et al. J Med Chem. 2009 Nov 12;52(21):6527-30.
2. Wong TW, et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.
3. Haluska P, et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98.
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