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Chemical Structure : BMS-599626 hydrochloride
CAS No.: 873837-23-1
Catalog No.: PC-42825Not For Human Use, Lab Use Only.
BMS-599626 (AC-480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $215 | In stock | |
| 50 mg | $360 | In stock | |
| 100 mg | $600 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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BMS-599626 (AC-480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM; displays 8-fold less potency to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc; inhibits the proliferation of tumor cells expressing high levels of HER1 and/or HER2; shows potent antitumor activity in a human breast tumor KPL-4 xenograft; orally efficacious.
Breast Cancer
Phase 1 Discontinued
| M.Wt | 567.0144 | |
| Formula | C27H28ClFN8O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester, monohydrochloride (9CI) |
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1. Gavai AV, et al. J Med Chem. 2009 Nov 12;52(21):6527-30.
2. Wong TW, et al. Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.
3. Haluska P, et al. Mol Cancer Ther. 2008 Sep;7(9):2589-98.
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