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Chemical Structure : BMS-690514
CAS No.: 859853-30-8
Catalog No.: PC-42532Not For Human Use, Lab Use Only.
BMS-690514 is a potent pan EGFR/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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BMS-690514 is a potent pan EGFR/VEGFR inhibitor with IC50 of 5/20/60/50 nM for EGFR/HER2/ERBB4/VEGFR2 respectively.
BMS-690514 exerts antiproliferative and proapoptotic effects on NSCLC cell lines, with prominent efficacy on H1975 cells expressing the T790M mutation; induces G1 cell cycle arrest.
| M.Wt | 368.4329 | |
| Formula | C19H24N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-Piperidinol, 4-amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]-, (3R,4R)- |
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1. de La Motte Rouge T, et al. Cancer Res. 2007 Jul 1;67(13):6253-62.
2. Wong TW, et al. Clin Cancer Res. 2011 Jun 15;17(12):4031-41.
3. Loriot Y, et al. Br J Cancer. 2010 Jul 27;103(3):347-53.
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