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BMS-929075

Chemical Structure : BMS-929075

CAS No.: 1217338-97-0

BMS-929075 (BMS 929075;BMS929075)

Catalog No.: PC-60427Not For Human Use, Lab Use Only.

A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively; possesses excellent pharmacokinetic parameters across preclinical animal species.

HCV Infection

Phase 1 Clinical

Physicochemical Properties

M.Wt 538.5548
Formula C31H24F2N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-Fluoro-2-(4-fluorophenyl)-N-methyl-5-[2-methyl-5-[[[1-(2-pyrimidinyl)cyclopropyl]amino]carbonyl]phenyl]-3-benzofurancarboxamide

References

1. Yeung KS, et al. J Med Chem. 2017 May 25;60(10):4369-4385.

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