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BMS-961955

Chemical Structure : BMS-961955

CAS No.: 1431328-92-5

BMS-961955 (BMS961955)

Catalog No.: PC-62847Not For Human Use, Lab Use Only.

BMS-961955 is an potent, allosteric inhibitor of HCV NS5B polymerase with EC50 of 7.9/4.3 nM for GT 1b/1a replicon respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BMS-961955 is an potent, allosteric inhibitor of HCV NS5B polymerase with EC50 of 7.9/4.3 nM for GT 1b/1a replicon respectively.
    BMS-961955 shows weak activity against PXR; displayes significantly enhanced metabolic stability in CLM and HLM.

    Physicochemical Properties

    M.Wt 658.833
    Formula C37H43FN4O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (4bS,5aR)-12-Cyclohexyl-3-fluoro-4b,5,5a,6-tetrahydro-N-[(1-methylcyclopropyl)sulfonyl]-5a-[(3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl]cycloprop[d]indolo[2,1-a][2]benzazepine-9-carboxamide

    References

    1. Zheng BZ, et al. Bioorg Med Chem Lett. 2017 Jun 11. pii: S0960-894X(17)30626-1.

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