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Chemical Structure : BMS 777607
CAS No.: 1025720-94-8
Catalog No.: PC-42888Not For Human Use, Lab Use Only.
BMS 777607 (ASLAN002) is a potent, selective, orally efficacious inhibitor of Met kinase with IC50 of 3.9 nM, also potently inhibits Ron, Axl, Tyro-3 and Mer (IC50<15 nM), 40-fold selectivity over Lck, VEGFR-2 and TrkA/B.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $18 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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BMS 777607 (ASLAN002) is a potent, selective, orally efficacious inhibitor of Met kinase with IC50 of 3.9 nM, also potently inhibits Ron, Axl, Tyro-3 and Mer (IC50<15 nM), 40-fold selectivity over Lck, VEGFR-2 and TrkA/B.
BMS 777607 inhibits cell scattering activated by exogenous HGF in c-Met-expressing PC-3 and DU145 prostate cancer cells, suppresses HGF-stimulated cell migration and invasion with IC50 of <0.1 uM.
BMS 777607 potently blocks HGF-stimulated c-Met autophosphorylation and downstream activation of Akt and ERK at nanomolar level.
BMS 777607 demonstrates complete tumor stasis in Met-dependent GTL-16 human gastric carcinoma xenograft models.
| M.Wt | 512.8926 | |
| Formula | C25H19ClF2N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 39 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboxamide, N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-1,2-dihydro-2-oxo- |
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1. Schroeder GM, et al. J Med Chem. 2009 Mar 12;52(5):1251-4.
2. Dai Y, et al. Mol Cancer Ther. 2010 Jun;9(6):1554-61.
3. Dai Y, et al. Clin Exp Metastasis. 2012 Mar;29(3):253-61.
4. Onken J, et al. Oncotarget. 2016 Mar 1;7(9):9876-89.
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