Chemical Structure : BNS808
CAS No.:
2836313-12-1
BNS808
(BNS-808)
Catalog No.: PC-24424Not For Human Use, Lab Use Only.
BNS808 is a potent, peripherally selective cannabinoid-1 receptor (CB1R) antagonist with Ki values of 0.7 nM for both mouse and human CB1R and IC50 of 0.8 nM (hCB1R), >2000-fold selective over CB2R.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BNS808 is a potent, peripherally selective cannabinoid-1 receptor (CB1R) antagonist with Ki values of 0.7 nM for both mouse and human CB1R and IC50 of 0.8 nM (hCB1R), >2000-fold selective over CB2R.
BNS808 does not induce CNS-mediated side effects.
BNS808 treatment (1 mg/kg/day, oral doses for 24 days.) reduced body weigh and fat mass and increases lean body mass in diet-induced obese mice.
Chronic BNS808 administration (1 mg/kg/day for 24 days) reduces HFD-induced hepatic steatosis and liver injury in diet-induced obese mice.
Physicochemical Properties
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M.Wt
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548.86
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Formula
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C25H20Cl3N3O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-chloro-N-[2-(2-chlorophenyl)-3-(4-chlorophenyl)-5,6,7,8-tetrahydrooxepino[3,2-c]pyrazol-8-yl]benzenesulfonamide
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References
1. Gammal A, et al. J Med Chem. 2025 Apr 21. doi: 10.1021/acs.jmedchem.4c03132.
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