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Chemical Structure : BNZ-1
Catalog No.: PC-38315Not For Human Use, Lab Use Only.
BNZ-1 (BNZ132-1-40) is a pegylated peptide, BNZ132-1 conjugated with methoxy-PEG40 maleimide molecule via a specific linker (CGSGG), specifically binds the γc receptor to selectively block IL-2, IL-15 and IL-9 signaling.
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BNZ-1 (BNZ132-1-40) is a pegylated peptide, BNZ132-1 conjugated with methoxy-PEG40 maleimide molecule via a specific linker (CGSGG), specifically binds the γc receptor to selectively block IL-2, IL-15 and IL-9 signaling; BNZ-1 (BNZ132-1-40) is a helical peptide designed to bind directly to the γc molecule and is PEGylated to increase its half-life, selectively block IL-2, IL-15, and IL-9 binding while leaving other γc and non-γc cytokine signaling unaffected. BNZ-1 effectively inhibited ex vivo HTLV-1 associated myelopathy/ tropical spastic paraparesis PBMC proliferation and in vivo proliferation of murine CD8+ T cell leukemia in an IL-15 transgenic mouse model. BNZ-1 exhibited no adverse effects on other immune cells and maintained selectivity for Tregs, CD8+ T and NK cells.
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1. Toshie Nata, et al. J Biol Chem. 2015 Sep 11;290(37):22338-51.
2. T Tiffany Wang, et al. Leukemia. 2019 May;33(5):1243-1255.
3. Raya Massoud, et al. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11030-5.
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