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Chemical Structure : BPTU
Catalog No.: PC-61413Not For Human Use, Lab Use Only.
A potent, highly selective and allosteric antagonist of P2Y1 receptor with Ki of 6 nM for hP2Y1.
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A potent, highly selective and allosteric antagonist of P2Y1 receptor with Ki of 6 nM for hP2Y1; shows no significant affinity for hP2Y2/6/11/12/14 (Ki>5 uM); inhibits purinergic inhibitory junction potentials and inhibition of spontaneous motility induced by electrical field stimulation in the colon of rats (EC50 = 0.3 uM) and mice (EC50 = 0.06 uM); also blocks nicotine induced relaxation; has reasonable plasma exposure, clearance and half-life with moderate oral bioavailability.
| M.Wt | 445.43 | |
| Formula | C23H22F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chao H, et al. J Med Chem. 2013 Feb 28;56(4):1704-14.
2. Mañé N, et al. Neuropharmacology. 2016 Nov;110(Pt A):376-385.
3. Zhang D, et al. Nature. 2015 Apr 16;520(7547):317-21.
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