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Chemical Structure : BQ-123
CAS No.: 136553-81-6
Catalog No.: PC-43010Not For Human Use, Lab Use Only.
BQ-123 (PMZ 2123) is a potent, selective, non-competitive cyclic pentapeptide ETA receptor antagonist with IC50 of 7.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $360 | In stock | |
| 10 mg | $580 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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BQ-123 (PMZ 2123) is a potent, selective, non-competitive cyclic pentapeptide ETA receptor antagonist with IC50 of 7.3 nM; antagonizes endothelin-1-induced contractions in rabbit aorta, increases in inositol phosphates in cultured rat vascular smooth muscle A10 cells, shifts concentration-response curves in isolated rabbit aorta elicited by angiotensin II, but does not bind to angiotensin II receptors nor affect angiotensin II-induced increases in inositol phosphates.
Diabetes
Phase 1 Clinical
| M.Wt | 610.7012 | |
| Formula | C31H42N6O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 34 mg/mL |
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| Chemical Name/SMILES |
Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl) |
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1. Ihara M, et al. J Cardiovasc Pharmacol. 1992;20 Suppl 12:S11-4.
2. Hiley CR, et al. Biochem Biophys Res Commun. 1992 Apr 15;184(1):504-10.
3. Ihara M, et al. Life Sci. 1992;50(4):247-55.
4. Webb ML, et al. Biochem Biophys Res Commun. 1992 Jun 30;185(3):887-92.
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