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Chemical Structure : BRD3308
CAS No.: 1550053-02-5
Catalog No.: PC-62401Not For Human Use, Lab Use Only.
BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms.
BRD3308 attenuates PE-mediated phosphorylation of ERK, but not JNK.
BRD3308 also activates HIV-1 transcription in the 2D10 cell line, induces outgrowth of HIV-1 from resting CD4+ T cells isolated from antiretroviral-treated, aviremic HIV+ patients ex vivo and disrupts HIV-1 latency.
BRD3308 suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release.
| M.Wt | 287.294 | |
| Formula | C15H14FN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4-Acetylamino-N-(2-amino-4-fluorophenyl)-benzamide |
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1. Ferguson BS, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9806-11.
2. Barton KM, et al. PLoS One. 2014 Aug 19;9(8):e102684.
3. Wagner FF, et al. ACS Chem Biol. 2016 Feb 19;11(2):363-74.
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