Chemical Structure : BRD3 PROTAC D072
CAS No.:
2257497-15-5
BRD3 PROTAC D072
(BRD3 degrader)
Catalog No.: PC-28728Not For Human Use, Lab Use Only.
BRD3 PROTAC D072 is a specific BRD3 degrader, shows potential anti-inflammatory effect in microglia.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BRD3 PROTAC D072 is a specific BRD3 degrader, shows potential anti-inflammatory effect in microglia.
D072 (10 nM) significantly inhibits proteins of iNOS, COX-2, and Galetcin-3 in LPS stimulated BV2 cells.
D072 alleviates the retinal severity of EAU and activation of retinal microglia.
D072 exerts anti-inflammatory effects by specifically degrading BRD3.
D072 (1 uM) induces significant reduction in BRD3 protein levels but has no effect on BRD2 and BRD4.
D072 mediates the specific degradation of BRD3 through CRBN.
D072 may exert its anti-inflammatory effects by modulating downstream target genes of H3K18ac.
Physicochemical Properties
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M.Wt
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946.09
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Formula
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C49H55N9O9S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-(3-((1-(11-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)undecyl)-1H-1,2,3-triazol-4-yl)methoxy)phenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide
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References
1. Zhang Z, et al. iScience. 2025 Dec 22;29(2):114526.
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